Child tumour subject of study

An international study that included doctors at Toronto’s Hospital for Sick Children appears to shed new light on a particular type of brain tumour in children that often proves deadly.

TORONTO — An international study that included doctors at Toronto’s Hospital for Sick Children appears to shed new light on a particular type of brain tumour in children that often proves deadly.

“We have the potential for a new diagnostic tool for a very aggressive type of brain tumour,” said Dr. Annie Huang, senior author of the study published by the journal Cancer Cell.

Because these tumours, known as CNS-PNETs, are extremely rare — there are only two or three found in patients at the large pediatric hospital each year — Huang asked hospitals around the world to contribute samples.

In the end, the researchers managed to gather 46 tumours, and found they had good data for 40 of them.

It’s the largest collection of this tumour type ever looked at, said Huang, whose team examined the genome of the tumours.

“In normal cells you always have two copies of DNA, and in tumours they tend to lose or gain parts of DNA,” she explained.

“And those usually tell you important locations for genes that are sort of driving a tumour process or not, or something that is maybe associated with a tumour.”

“What we found was that about a quarter of our tumours had this very unusual area, where it had many copies of this particular area.

“I say area because it encompassed more than one gene.”

When the researchers looked closely, they found 34 regular genes, as well as two clusters of a “very newly described class of genes, called microRNAs,” she said.

They believe these clusters represent a marker for highly aggressive disease in children under age four, which is typically fatal.

Just Posted

City watching speed limit debate

Blackfalds, Calgary and Edmonton the latest to consider reduced residential speed limits

UPDATED: Missing woman found

RCMP thank pubic for their assistance

Late bidding war drives Stampede sponsorship auction to $3.29M bid total

CALGARY — An unexpected late bidding war for the right to sponsor… Continue reading

Mother Russia: South Florida sees a boom in ‘birth tourism’

MIAMI — Every year, hundreds of pregnant Russian women travel to the… Continue reading

Air Canada, WestJet purchased safety option reportedly missing on crashed planes

TORONTO — Canada’s two largest airlines have at least one of the… Continue reading

Flyers, Blackhawks, Sabres and Lightning to Europe in ‘19-20

Jakub Voracek was psyched at the mere suggestion the Philadelphia Flyers might… Continue reading

Danish receiver Nielsen looking to defy the odds again, this time at CFL combine

TORONTO — He’s coming to the CFL’s national combine as a definite… Continue reading

Mom with kids on YouTube channel suspected of child abuse

MARICOPA, Ariz. — A woman who operated a popular YouTube channel featuring… Continue reading

Richie Mehta’s ‘Delhi Crime’ series, about 2012 rape case, hits Netflix

A drama series made by Indo-Canadian filmmaker Richie Mehta and based on… Continue reading

Local Sports: Queen’s Avery Lajeunesse not afraid to get physical

A year ago Avery Lajeunesse made a commitment to join the RDC… Continue reading

Seniors: Exposing the hype surrounding supplements

Do we need dietary supplements as we age? Do these supplements actually… Continue reading

Eight warning signs you won’t finish college

Forty per cent of students who enrol in a four-year college don’t… Continue reading

Photos: Deer spotted in Red Deer

Spring has sprung. One Advocate reader has been seeing a herd of… Continue reading

Most Read