Child tumour subject of study

An international study that included doctors at Toronto’s Hospital for Sick Children appears to shed new light on a particular type of brain tumour in children that often proves deadly.

TORONTO — An international study that included doctors at Toronto’s Hospital for Sick Children appears to shed new light on a particular type of brain tumour in children that often proves deadly.

“We have the potential for a new diagnostic tool for a very aggressive type of brain tumour,” said Dr. Annie Huang, senior author of the study published by the journal Cancer Cell.

Because these tumours, known as CNS-PNETs, are extremely rare — there are only two or three found in patients at the large pediatric hospital each year — Huang asked hospitals around the world to contribute samples.

In the end, the researchers managed to gather 46 tumours, and found they had good data for 40 of them.

It’s the largest collection of this tumour type ever looked at, said Huang, whose team examined the genome of the tumours.

“In normal cells you always have two copies of DNA, and in tumours they tend to lose or gain parts of DNA,” she explained.

“And those usually tell you important locations for genes that are sort of driving a tumour process or not, or something that is maybe associated with a tumour.”

“What we found was that about a quarter of our tumours had this very unusual area, where it had many copies of this particular area.

“I say area because it encompassed more than one gene.”

When the researchers looked closely, they found 34 regular genes, as well as two clusters of a “very newly described class of genes, called microRNAs,” she said.

They believe these clusters represent a marker for highly aggressive disease in children under age four, which is typically fatal.

Just Posted

Motorcross riders perform heart-stopping stunts at Red Deer’s Westerner Days

‘I wanted to see how far I could push myself and my machine,’ says rider

Oil and gas well cleanup costs could hit $65 billion, says industry watchdog

Alberta government urged to undertake detailed review of cleanup costs

Fatal disease strikes Alberta sheep

Scrapie detected on two Alberta farms

UCP candidate fined $70,000

Penalty against Jeff Callaway is for two dozen separate offences

Chris Sale snaps Fenway losing streak, beats Blue Jays 5-0

Red Sox 5 Blue Jays 0 BOSTON — That was a relief.… Continue reading

Critics and industry clash over accuracy of Alberta well cleanup cost estimates

CALGARY — An Alberta coalition that says oil and gas producers are… Continue reading

Man shouting ‘You die’ kills 33 at Japan anime studio

TOKYO — A man screaming “You die!” burst into an animation studio… Continue reading

Documents shed light on seniors poverty figures used by federal Liberals

OTTAWA — Internal government documents say that many of the 57,000 seniors… Continue reading

High court won’t hear NDP expenses case over mailings, offices

OTTAWA — The Supreme Court may have just killed off the NDP’s… Continue reading

Justin Trudeau takes aim at NDP over EU-Canada trade pact as summit wraps up

MONTREAL — Prime Minister Justin Trudeau is calling out New Democrats after… Continue reading

Defence calling no evidence in case of German tourist shot west of Calgary

CALGARY — The defence is calling no evidence on behalf of a… Continue reading

Tale of two libraries: Edmonton design backlash morphs into rivalry with Calgary

EDMONTON — The pitched reaction to Edmonton’s remodelled downtown library has morphed… Continue reading

Most Read