Child tumour subject of study

An international study that included doctors at Toronto’s Hospital for Sick Children appears to shed new light on a particular type of brain tumour in children that often proves deadly.

TORONTO — An international study that included doctors at Toronto’s Hospital for Sick Children appears to shed new light on a particular type of brain tumour in children that often proves deadly.

“We have the potential for a new diagnostic tool for a very aggressive type of brain tumour,” said Dr. Annie Huang, senior author of the study published by the journal Cancer Cell.

Because these tumours, known as CNS-PNETs, are extremely rare — there are only two or three found in patients at the large pediatric hospital each year — Huang asked hospitals around the world to contribute samples.

In the end, the researchers managed to gather 46 tumours, and found they had good data for 40 of them.

It’s the largest collection of this tumour type ever looked at, said Huang, whose team examined the genome of the tumours.

“In normal cells you always have two copies of DNA, and in tumours they tend to lose or gain parts of DNA,” she explained.

“And those usually tell you important locations for genes that are sort of driving a tumour process or not, or something that is maybe associated with a tumour.”

“What we found was that about a quarter of our tumours had this very unusual area, where it had many copies of this particular area.

“I say area because it encompassed more than one gene.”

When the researchers looked closely, they found 34 regular genes, as well as two clusters of a “very newly described class of genes, called microRNAs,” she said.

They believe these clusters represent a marker for highly aggressive disease in children under age four, which is typically fatal.

Just Posted

Councillors want to represent Red Deer at AUMA

City council approves endorsement

Cannabis smoke raises health concerns

Smoke Free Bylaw returns to Red Deer city council Sept. 4

Avid Penhold climber Catlin Hannah’s death a reminder of the dangers of scrambling

Hannah never returned from his Mount Smuts attempt on Aug. 12.

Children, elderly at risk as smoke from distant fires hangs over parts of B.C.

VANCOUVER — Thick smoke blanketing British Columbia communities far from any flames… Continue reading

WATCH: Medicine River Wildlife Centre opens new playground

The grand opening of the playground was Saturday morning

Police chiefs want new data-sharing treaty with U.S. as privacy questions linger

OTTAWA — Canada’s police chiefs are pressing the Trudeau government to sign… Continue reading

Pope on sex abuse: “We showed no care for the little ones”

VATICAN CITY — Pope Francis issued a letter to Catholics around the… Continue reading

Ottawa announces $189M to extend employment insurance for seasonal workers

ESCUMINAC, N.B. — Ottawa has announced $189 million for an employment insurance… Continue reading

Trudeau formally announces he’ll run again in next year’s election

MONTREAL — Justin Trudeau will run again in the 2019 federal election.… Continue reading

Smoke from B.C. wildfires prompts air quality advisories across Western Canada

VANCOUVER — More smoky, hazy air is expected to blanket much of… Continue reading

Anti-pipeline protesters released days before weeklong jail sentences end

MAPLE RIDGE, B.C. — Several pipeline protesters were released from a British… Continue reading

All eyes on Andrew Scheer as Conservative convention set for Halifax

OTTAWA — After a week of internal caucus squabbles, Conservative Leader Andrew… Continue reading

Trump says his White House counsel not a ‘RAT’ like Nixon’s

BRIDGEWATER, N.J. — President Donald Trump insisted Sunday that his White House… Continue reading

Most Read

Five-day delivery plus unlimited digital access for $185 for 260 issues (must live in delivery area to qualify) Unlimited Digital Access 99 cents for the first four weeks and then only $15 per month Five-day delivery plus unlimited digital access for $15 a month