FDA approves diabetes drug that also helps with weight loss

  • Dec. 5, 2017 2:26 p.m.

TRENTON, N.J. — U.S. regulators on Tuesday approved a new diabetes drug that reduces blood sugar levels and also helps people lose significant weight.

Danish drugmaker Novo Nordisk said the Food and Drug Administration approved its once-a-week shot for people with Type 2 diabetes. The drug, Ozempic, also known as semaglutide, works by stimulating the body’s own insulin production and reducing appetite.

In one big company-funded study, Ozempic, on average, reduced long-term blood sugar levels at least 2 1/2 times as much as a popular daily diabetes pill, Merck & Co.’s Januvia. It also helped study participants lose two to three times as much weight as those in the comparison group.

Over 56 weeks, patients who got a lower dose of Ozempic lost an average of 9.5 pounds (4.3 kilograms) while those who got a higher dose lost 13.5 pounds (6.1 kilograms). The patients who took Januvia lost an average of 4 pounds (1.9 kilograms).

The 1,200 study participants were also taking one or two standard diabetes medicines.

Novo Nordisk, a leader in diabetes care, has also been testing the drug separately for weight loss alone.

Many Type 2 diabetes patients are overweight or obese, and losing significant weight usually helps them reduce their blood sugar and better control their diabetes. Over time, too high sugar in the blood can damage multiple organs and weaken circulation.

The new drug comes in injector pens and costs about the same as similar weekly drugs: $676 for a four- to six-week supply without insurance. Novo Nordisk already sells a similar once-a-day shot, Victoza.

Ozempic will compete with other popular once-a-week drugs in the same class, including Eli Lilly and Co.’s Trulicity and AstraZeneca PLC’s Bydureon, which don’t produce as much weight loss. However, they all carry warnings about possible serious side effects, including kidney damage and inflammation of the pancreas. They also may be linked to thyroid cancer, so people taking all drugs in the class are being followed via a patient registry.

Januvia is in a different drug class.

Get local stories you won't find anywhere else right to your inbox.
Sign up here

Just Posted

A nurse gets a swab ready at a temporary COVID-19 test clinic in Montreal, on Friday, May 15, 2020. Health Canada has reversed course on home test kits for COVID-19, saying it will now review applications for such devices. THE CANADIAN PRESS/Paul Chiasson
Alberta declines Ontario’s request to send health-care workers

Alberta is “not in a position” to send health-care workers out of… Continue reading

The Red Deer Rebels allowed four straight goals from the Medicine Hat Tigers Friday night on the road. (Photo by Rob Wallator/ Red Deer Rebels)
Tigers hand Red Deer Rebels 10th straight loss

Tigers 4 Rebels 2 Through 17 games in the shortened WHL season,… Continue reading

Meghan Huizing has been selected by Red Deer Catholic Regional Schools as a finalist for the Alberta School Boards Association (ASBA) 2021 Edwin Parr Award. (Photo courtesy of Red Deer Regional Catholic Schools)
Red Deer Catholic names finalist for Edwin Parr Award

Meghan Huizing from St. Gregory the Great Catholic School in Blackfalds has… Continue reading

GrammaLink-Africa members are participating in the Stride to Turn the Tide campaign until June 30. (Contributed photo)
Red Deer group walking to raise money for African grandmothers

A group of central Albertans will be walking every day until the… Continue reading

Red Deer Public Schools will not pilot the new draft curriculum at its elementary schools. (File photo contributed by Red Deer Public Schools)
UPDATED: Red Deer Public Schools says no to piloting new curriculum

Alberta Teachers’ Association support school boards

Montreal Canadiens' Tyler Toffoli celebrates his goal past Calgary Flames goaltender Jacob Markstrom during second-period NHL hockey action in Montreal on Friday, April 16, 2021. THE CANADIAN PRESS/Paul Chiasson
Toffoli scores twice, Canadiens put some distance on Flames with 2-1 win

Toffoli scores twice, Canadiens put some distance on Flames with 2-1 win

Canadian prop Jake Ilnicki savouring life in Seattle, looks forward to facing Arrows

Canadian prop Jake Ilnicki savouring life in Seattle, looks forward to facing Arrows

Corey Conners, of Canada, hits out of a bunker on the seventh hole during the final round of the Masters golf tournament in Augusta, Ga., Sunday, April 11, 2021. Conners notched six birdies on his back nine to take the lead after his second round of the RBC Heritage on Friday. THE CANADIAN PRESS/AP-Matt Slocum
Canadian Corey Conners surges into lead at PGA Tour’s RBC Heritage

Canadian Corey Conners surges into lead at PGA Tour’s RBC Heritage

Patrick Marleau poised to break Gordie Howe’s games record

Patrick Marleau poised to break Gordie Howe’s games record

Leylah Annie Fernandez of Canada serves to Marie Bouzkova of the Czech Republic in round 1 of the Rogers Cup women's tennis tournament in Toronto, Monday August 5, 2019. THE CANADIAN PRESS/Mark Blinch
Rebecca Marino propels Canada into 2-0 lead over Serbia at Billie Jean King Cup

Rebecca Marino propels Canada into 2-0 lead over Serbia at Billie Jean King Cup

Dalton Kellett pulls out of the pits during a practice session for the Indianapolis 500 auto race at Indianapolis Motor Speedway, in Indianapolis, Thursday, Aug. 13, 2020. Dalton Kellett is pleased his second career season in IndyCar will be different than his first, which started on an elaborate iRacing rig in his home office in Indianapolis because of COVID-19 restrictions. THE CANADIAN PRESS/AP-Darron Cummings
Canada’s Dalton Kellett set for a more stable season as an IndyCar driver

Canada’s Dalton Kellett set for a more stable season as an IndyCar driver

Canada head coach Bev Priestman reacts during the women's international friendly soccer match between England and Canada at Bet365 stadium in Stoke on Trent, England, Tuesday, April 13, 2021. THE CANADIAN PRESS/AP/Rui Vieira
Canadian women get peek at their possible road at Olympic soccer tournament

Canadian women get peek at their possible road at Olympic soccer tournament

Head coach John Tait talks to his team as Canada takes on Japan in women's sevens rugby action at the 2016 Olympic Games in Rio de Janeiro, Brazil on Saturday, Aug. 6, 2016. THE CANADIAN PRESS/Sean Kilpatrick
Rugby Canada says probe into complaint from members of women’s 7s team is complete

Rugby Canada says probe into complaint from members of women’s 7s team is complete

Most Read