‘Overdiagnosis epidemic’ in thyroid cancer: study

CALGARY — A study by researchers at the University of Calgary suggests most people treated for thyroid cancer have tumours that would never pose any harm.

Dawnelle Topstad and James Dickinson, with the university’s Cumming School of Medicine, pored over four decades worth of Canadian data on the disease.

They found thyroid cancer incidence rates in Canada increased by almost six times in women and five times in men between 1970 and 2012.

There was a big spike after the early 1990s, when ultrasound technology came into wide use. The sharpest increase was in women between 40 and 60.

At the same time, the rates of people who died from the disease were low throughout the period, with little variation between men and women.

“The likely cause of the increase in incidence is an overdiagnosis epidemic for clinically unimportant lesions detected by modern diagnostic imaging,” Topstad and Dickinson wrote.

Dickinson said roughly 75 per cent of cases are harmless. Abnormal cells may be present, but the mass would never grow or would grow too slowly to cause any problems.

“The tendency for all of us is to say ‘Well, we’ve got to make sure that we don’t miss any cancers.’ And that’s entirely appropriate,” he said in an interview. “But the difficulty is that then leads to over-calling. That leads to overdiagnosis and causes harm.”

Medical professionals have had a hard time balancing the risks of the tumours themselves against the risk of treating them, he said.

“It’s not easy, but we have to face up to it,” he said. “At the moment, by not having been critical enough, we’ve now created a lot of harm.”

Treatment for thyroid cancer can include surgery and radioactive iodine followed by lifelong hormone replacement drugs. Operating on the thyroid gland could endanger vital blood vessels and nerves in the area if there are complications.

“The neck is tiger country,” Dickinson said.

He said the effects of radioactive iodine are fairly isolated and short-lived.

In the long term, it’s a delicate balance to replace the hormones that the gland produced, since the wrong dosage can have dangerous side effects. For instance, an overabundance can lead to high blood pressure.

“You’re then tied to the medical system for the rest of your life,” said Dickinson.

The study noted sharp regional differences — Ontario had a thyroid cancer incidence rate in 2012 twice that of British Columbia. After discounting possibilities such as increased radiation exposure, obesity and diabetes rates, Dickinson said the researchers suspect the availability of ultrasound testing was the cause.

As for why the rates are so much higher in women than men — 23.4 per 100,000 in 2012 for women compared to 7.2 per 100,000 that year for men — Dickinson said it could be that women are more likely to visit their doctors if they feel something’s amiss.

“Further effort should concentrate on reducing overuse of diagnostic imaging and finding better ways to distinguish those patients with unimportant indolent tumours, while still identifying aggressive thyroid cancer that needs treatment,” Topstad and Dickinson wrote in the paper, which was published this week in CMAJ Open.

Dickinson said there are lessons to be drawn for family physicians, radiologists, pathologists and surgeons.

“Everybody plays their part in focusing on treating the right ones and not treating the others.”

Just Posted

Women raising alarm about BBQ brushes

Beverly Smith’s ended up in an operating room after wire bristle pierced her bowel

Ban barbecue brushes: doctor

Brushes pose a health risk because wire bristles can get ingested

Live play and creche display in Red Deer open to the public

Church hosting live nativity, creche display A mainstay of some Red Deerians’… Continue reading

WATCH: Red Deer Royals nearing 50 years

The Red Deer Royals are a second family to Elise Bluett. The… Continue reading

Expect cooler temperatures and ‘dusting of snow’ this Christmas

Red Deer recorded a high temperature on Tuesday

Bed shortage means no mental reviews done yet on accused Edmonton attacker

A man accused of attempted murder after a police officer was hit… Continue reading

Update: Police release photo of suspected vehicle involved in fatal

Motorist dies near Ponoka after loose tire collides with vehicle near Ponoka

Notley criticizes MLA who fired staffer after sex harassment complaint

Notley says if Jason Nixon was her house leader he’d be out of a job immediately.

Red Deer needs to find a solution to syringe debris: city manager

City will consider the problem during the 2018 operating budget talks

WestJet Christmas video turns children’s wishes into reality

This year’s annual video took a new spin on the 12 days of Christmas

VIDEO: Replay Red Deer Dec. 10

Watch news highlights from Red Deer and Central Alberta

Most Read


Five-day delivery plus unlimited digital access for $185 for 260 issues (must live in delivery area to qualify) Unlimited Digital Access 99 cents for the first four weeks and then only $15 per month Five-day delivery plus unlimited digital access for $15 a month