Garoppolo throws 4 TD passes, 49ers beat Cardinals 28-25

GLENDALE, Ariz. — Jimmy Garoppolo threw for 317 yards and four touchdowns and the San Francisco 49ers reached the halfway point of their season undefeated, beating the Arizona Cardinals 28-25 on Thursday night.

San Francisco (8-0) fell behind 7-0, but responded with three touchdowns — one as time expired in the second quarter after Cardinals coach Kliff Kingsbury called a timeout and gave the 49ers a second chance on fourth down — to take a 21-7 halftime lead.

The 49ers were in control until about five minutes left in the fourth quarter, when Andy Isabella caught a short pass and sprinted for an 88-yard touchdown to help the Cardinals pull to 28-25.

But the 49ers were able to run out the clock on their ensuing offensive drive to end Arizona’s comeback. San Francisco’s Emmanuel Sanders caught seven passes for 112 yards and a touchdown.

Arizona (3-5-1) lost its second straight game. Rookie quarterback Kyler Murray threw for 241 yards and two touchdowns.

The Cardinals came into the game without their top two running backs, David Johnson and Chase Edmonds, who were battling injuries.

Kenyan Drake — who was acquired by the Cardinals on Monday in a trade with the Miami Dolphins — ran for 36s yard on the first play of the game and capped the opening drive with a 4-yard touchdown run. He finished with a team-high 110 yards rushing and 52 yards receiving.

BAD TIMING

Arizona looked as if was about to escape the first half trailing 14-7 after San Francisco’s Jeff Wilson Jr. was stopped on fourth down just shy of the goal line with a few seconds remaining in the first half.

But there was one major problem for the Cardinals: Kingsbury called a timeout just before the play began.

The 49ers converted on their second chance when Garoppolo hit Sanders for a 1-yard touchdown pass and a 21-7 lead.

ROAD WARRIORS

San Francisco’s off to an 8-0 start for the second time in franchise history. The Niners won 10 straight games to start the 1990 season.

This year’s streak has included five road wins. The 49ers have three straight home games starting with the Seahawks on Nov. 11.

KITTLE SCARE

The 49ers got a scare early when star tight end George Kittle left the game after taking a helmet to the knee. But the third-year star quickly returned and responded with a 30-yard touchdown catch late in the first quarter to tie it at 7.

INJURIES

49ers: Defensive lineman Arik Armstead left in the first quarter with a throat injury but returned to the game. … Linebacker Kwon Alexander had a chest injury in the second half and didn’t return.

Cardinals: Defensive lineman Clinton McDonald left with what a “stinger” in the third quarter.

UP NEXT

San Francisco returns home to face Seattle on Nov. 11 for a Monday night game.

Arizona travels to Tampa Bay on Nov. 10.

Get local stories you won't find anywhere else right to your inbox.
Sign up here

Just Posted

RCMP investigate possible drowning at Pigeon Lake: Man and woman found dead on shore

Bodies recovered from Pigeon Lake’s northeastern shores.

Red Deer Region Highland Dancing Association to participate in national dance-a-thon

Central Albertan dancers have missed performing during the COVID-19 pandemic, says the… Continue reading

Maskwacis teen charged in 10-year-old boy’s death

The RCMP Major Crimes Unit have laid a manslaughter charge against a 13-year-old boy from Maskwacis.

Still no mandatory masks in Red Deer

While a growing number of Alberta communities have made masks mandatory, the… Continue reading

Cast your votes for Best of Red Deer

The Advocate’s Best of Red Deer Readers’ Choice Awards are back. Community… Continue reading

69 salmonella cases in B.C. linked to red onions, province’s CDC says

VANCOUVER — The BC Centre for Disease Control is warning people in… Continue reading

Puncher’s chance: Fighting is up during unique NHL playoffs

The Toronto Maple Leafs’ season was hanging by a thread from one… Continue reading

Quebec festivals organizers look to innovate as restrictions loosened

Montreal has been having its quietest summer in recent memory, as COVID-19… Continue reading

COVID-19 outbreaks over in federal prisons, staff preparing for ‘new normal’

COVID-19 outbreaks in Canada’s federal prisons have been declared over, and staff… Continue reading

Canada to match donations to Lebanon relief

OTTAWA — The federal government will match all individual donations from Canadians… Continue reading

Protests in Beirut amid public fury over massive blast

BEIRUT — Police fired tear gas and clashed with demonstrators in Lebanon’s… Continue reading

Most Read