Study finds no blocked neck veins in MS patients

A long-awaited Canadian study has found no evidence that blocked neck veins or impaired blood flow are connected with multiple sclerosis, the most recent of several international trials that have called the hypothetical link with MS into question.

TORONTO — A long-awaited Canadian study has found no evidence that blocked neck veins or impaired blood flow are connected with multiple sclerosis, the most recent of several international trials that have called the hypothetical link with MS into question.

But instead of debunking the theory once and for all, the findings only appear to have fuelled the debate as to whether abnormal veins in the neck and chest are somehow involved with the progressive and debilitating neurological condition.

The idea was first put forward by Italian vascular surgeon Paulo Zamboni, who hypothesized in 2009 that narrowed and twisted veins in the neck and chest create a backup of blood in the brain, resulting in iron deposits that could cause the lesions typical of MS.

Zamboni dubbed the abnormality “chronic cerebrospinal venous insufficiency,” or CCSVI. He suggested it might be a cause of MS and that opening up the veins with balloon angioplasty, the same procedure used to unblock coronary arteries, could help relieve symptoms and might even stop progression of the disease.

In a study he performed on MS patients, Zamboni said specialized ultrasound testing showed neck vein anomalies in 100 per cent of subjects.

Since then, researchers around the world have conducted their own studies, using ultrasound and other imaging techniques, but none has come close to replicating Zamboni’s results.

The latest is the group from McMaster University in Hamilton, which used both ultrasound and MRI testing on 100 MS patients and 100 healthy control subjects. The study was blinded — meaning researchers did not know which subjects had MS and which ones had no neurological disease — until the data analysis was completed.

“When we broke the codes, we suddenly realized, my goodness gracious, there’s a very, very clear endpoint to this study — we have no evidence whatsoever of CCSVI,” said principal investigator Ian Rodger, professor emeritus in the department of medicine at McMaster.

“When we looked at the MRI (blood) flow and when we looked at the ultrasound flow, we saw again that there is nothing that differentiates the two sets of groups, MS from control,” Rodger said from Hamilton. “We saw no evidence at all of narrowing of the vessels, which is called stenosis or a blockage. We didn’t see reflux (blood backup).

“So at the end of the day, we had black-and-white information that suggested there’s no evidence of CCSVI.”

The researchers, whose paper was published Wednesday in the journal PLoS One, were careful to perform the ultrasound imaging using Zamboni’s method. Two “very skilled” ultrasonographers and McMaster’s chief of radiology spent a week in Ferrara, Italy, learning his exact technique.

Rodger said the researchers wanted to avoid any suggestion that their ultrasounds differed from Zamboni’s, a criticism levelled at some previous studies to explain why their results contradicted the Italian doctor’s across-the-board positive findings.

The Canadian MS patients represented the spectrum of the disease: benign; relapsing and remitting; secondary progressive; and primary progressive. MRI scans of neck and chest veins were done as a means of validating ultrasound scans, which were both performed the same day.

Despite the somewhat surprising results, Rodger said the goal was to perform a rigorously controlled study.

“From the standpoint of a scientist, the best thing you can come out with is that it’s very clear one way or the other. And this is obviously remarkably clear.”

Some other researchers, however, don’t agree.

Neurologist Dr. Anthony Traboulsee of the University of British Columbia is heading a $6-million federally funded trial of vein-opening angioplasty — Zamboni’s so-called “liberation therapy” — among Canadian participants.

Traboulsee said ultrasound and MRI are not reliable tests to detect CCSVI on their own, but need to be used in conjunction with the gold standard test called catheter venography.

That test involves feeding a tube (catheter) through blood vessels from the groin area, up into the jugular and other neck and chest veins so they can be viewed from inside — not from the outside as is the case with ultrasound and MRI scans.

While the McMaster team is “very experienced” and their study was well-designed, Traboulsee said Wednesday from Vancouver, “my concern is with the ultrasound.”

Widely varying results from ultrasound studies by research groups worldwide — including a University of Buffalo study that found 56 per cent of MS patients and 23 per cent of healthy controls had CCSVI — are a reflection of the subjective nature of interpreting ultrasounds, he said.

“I don’t think ultrasound is reliable to make definitive conclusions about Zamboni’s original theory or (in) any other papers that have come out since.”

Using catheter venography, his team has found CCSVI in close to 60 per cent of patients, he said of a soon-to-be published study.

Traboulsee said the McMaster results won’t affect the federal study, which will compare how patients given balloon angioplasty fare compared to those given a sham treatment.

“The Hamilton study is out of keeping with our findings, and we really don’t think it’s going to impact on how we’re going to continue to go forward,” he said, adding that enrolment has begun but results aren’t expected before 2016.

Dr. Adnan Siddiqui, director of neurosurgical research at the University of Buffalo, said he’s not sure what the McMaster paper adds to the debate, “other than this is one more study in the ’nay’ column rather than the ’yea’ column as far as CCSVI is concerned.”

Siddiqui, co-principal investigator of the university’s CCSVI-MS studies, said even catheter venography doesn’t appear to be sensitive enough to pick up neck and chest vein anomalies. The Buffalo group has tested another technique called intravascular ultrasound, which looks inside the veins, and said it appears to be superior to other diagnostic methods.

“I think we are still beginning to evaluate venous anatomy and venous drainage,” he said from Buffalo. “We don’t understand that well. We understand the arterial side exceptionally well.

“When it comes to venous disease, it’s extremely limited. And so that’s probably the biggest reason why things are all over the map.”

One thing Rodger and the other researchers do agree about, however, is that people with MS should only have the vein-opening treatment within the confines of a rigorously controlled clinical trial. And under no circumstances should stents — small mesh tubes — be used to prop open veins because of the danger they could migrate elsewhere in the body.

An estimated 30,000 MS patients worldwide have sought the therapy in clinics that have popped up in such countries as Poland, Bulgaria, India and Mexico, many of which use stents. Included among those medical tourists are thousands of Canadians with MS: the unproven treatment is not offered in Canada.

An estimated 55,000 to 75,000 Canadians have MS, and the country has one of the highest rates of the incurable disease in the world. MS causes the destruction of myelin, the protective sheath around nerves throughout the body, leading to progressive physical and cognitive disability.

Just Posted

Alberta Chief Medical Officer of Health Dr. Deena Hinshaw said Alberta’s declining COVID-19 numbers are a positive sign for the province. (photo by Chris Schwarz/Government of Alberta)
Red Deer down to 634 active COVID-19 cases

Central zone down to 2,054 active cases

Brandon Wheat Kings defenceman Rylan Thiessen (26) guards the front of the net as goalie Connor Unger makes a save on Winnipeg Ice forward Skyler Bruce during a Western Hockey League game on April 14 at the Brandt Centre in Regina. Brandon won 5-3. (Keith Hershmiller Photography)
Two big trades provide stability for Red Deer Rebels

All Connor Ungar wanted was an opportunity and he’s finally found it.… Continue reading

Seven central Alberta charities benefit from community foundation grants

Seven central Alberta charities have received grants from the Red Deer and… Continue reading

Red Deer Gun Show organizer, Harold Drok, is concerned $1 fee from each ticket sale will go to Westerner Park once shows can be restarted there. This new policy replaces parking fees which will be waived for future Westerner Park events. (Black Press file photo)
Event organizer concerned about Westerner Park’s new parking fee model

A show organizer is concerned this could impact proceeds

A rodeo south of Bowden drew a huge crowd on May 1 and 2, 2021. (Photo courtesy Mom’s Diner’s Facebook page)
Organizers of central Alberta anti-lockdown rodeo plead not guilty

Ty and Gail Northcott charged under the Public Health Act

Red Deer musician Curtis Phagoo is glad the Alberta government is investing $2 million to help the province’s live music industry, but he would have liked the criteria to be expanded, so the money could be used as relief to cover revenue shortfalls. (Contributed photo by Cory Michaud)
Red Deer musicians welcome $2M in grants to help live music, but would have preferred relief program

The money is for future projects and can’t be used for retroactive expenses

This image shows an assortment of gift options for dinner hosts, from left, Clark and Hopkins hot sauces, a Finamill spice grinder, sculptural candles from Greentree Home Candles, a Mosser Cake Stand topped with folded linen runners and a loaf of bread from Zingerman's, and a variety of Frank Lloyd Wright candles from the Art Institute of Chicago. (Cheyenne Cohen via AP)
Gathering again? Gifts to wow and thank your host

Gathering again? Gifts to wow and thank your host

FILE - This microscope image made available by the National Cancer Institute Center for Cancer Research in 2015 shows human colon cancer cells with the nuclei stained red. Americans should start getting screened for colon cancer earlier, at age 45 instead of waiting until they're 50, according to new guidelines from the U.S. Preventive Services Task Force, released on Tuesday, May 18, 2021. (NCI Center for Cancer Research via AP, File)
Americans urged to get colon cancer screening earlier

Americans urged to get colon cancer screening earlier

Defense attorney Dick DeGuerin appears before Judge Mark E. Windham who denied an emergency motion by the defense team seeking to postpone the trial today. during the murder trial of Robert Durst Monday, May 17, 2021, in Inglewood, Calif. The murder trial of the multimillionaire has resumed in Los Angeles County after a 14-month recess without the defendant present and with arguments about whether the case should continue at all. (Al Seib/Los Angeles Times via AP, Pool)
Prosecutor says Durst’s own words show his guilt in killings

Prosecutor says Durst’s own words show his guilt in killings

FILE - In this April 16, 2020, file photo, the Amazon logo is displayed in Douai, northern France. Amazon said Tuesday, May 18, 2021, that it will continue to ban police use of its face-recognition technology beyond the one-year ban it announced last year.  (AP Photo/Michel Spingler, File)
Amazon to extend pause on police use of facial recognition

Amazon to extend pause on police use of facial recognition

FILE - In this Thursday, Oct. 10, 2019, file photo, Philanthropist and Co-Chairman of the Bill & Melinda Gates Foundation Bill Gates gestures as he speaks to the audience during the Global Fund to Fight AIDS event at the Lyon's congress hall, central France. Despite damaging allegations suggesting Bill Gates pursued women who worked for him, don't expect changes to his roles at the two iconic institutions he co-founded, Microsoft and his namesake philanthropic foundation, raising accountability concerns from critics. (Ludovic Marin/Pool Photo via AP, File)
Bill Gates’ leadership roles stay intact despite allegations

Bill Gates’ leadership roles stay intact despite allegations

US Secretary of State Antony Blinken speaks during a joint press conference following meetings with the Icelandic Foreign Minister Gudlaugur Thor Thordarson, at the Harpa Concert Hall in Reykjavik, Iceland, Tuesday, May 18, 2021. Blinken is touting the Biden administration's abrupt shift in its predecessor's climate policies as he visits Iceland for talks with senior officials from the world's Arctic nations. (Saul Loeb/Pool Photo via AP)
AP source: US encouraging Israel to wind down Gaza offensive

AP source: US encouraging Israel to wind down Gaza offensive

People take pictures of a damaged synagogue after it was hit by a rocket fired from the Gaza Strip, in Ashkelon, Israel, Sunday, May 16, 2021. (AP Photo/Tsafrir Abayov)
Palestinians go on strike as Israel-Hamas fighting rages

Palestinians go on strike as Israel-Hamas fighting rages

The Banff National Park entrance is shown in Banff, Alta., Tuesday, March 24, 2020. THE CANADIAN PRESS/Jeff McIntosh
Minister asks Canadians to camp carefully in national parks as season starts

Minister asks Canadians to camp carefully in national parks as season starts

Most Read